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Clonazepam is a benzodiazepine derivative that has anxiolytics, anticonvulsants and muscle relaxant properties. Roche distributes it in the United States. This drug is prescribed in treating the following conditions: epilepsy, panic disorders, anxiety disorders, bruxism, restless leg syndrome and rapid eye movement behavior disorder. There are studies conducted that those who is suffering from acute epilepsy that is treated by this drug via intravenous administration and 72.5% showed improved EEG, 17.5 % showed no improvement and 10% had worst EEG readings. This drug is sometimes used in treating refractory epilepsies but it is not recommended for long term used because of tolerance on the drug. This drug has been found to be also effective in treating acute control of nonconvulsive status epilepticus. This drug is not recommended for management of seizures that is related to west syndrome, an age dependent epilepsy affection the very young. This drug is also highly effective as short term adjunct therapy to SSRI and clinical depression in reducing the SSRI adverse effects. This drug was approved in the United States in 1997 and now marketed by several companies. This drug is in the form of tablets, disintegrating tablets, oral solution and also solution for injection or intravenous infusion. The tablets are available in 0.5, 1 and 2 mg. The orally disintegratiing tablets are at 0.125, 0.25, 0.5, 1.0 and 2 mg respectively. The oral solution is in 2.5 mg/ml and the intravenous solution is at 1 mg per ampule.

The action of this drug is where Clonazepam exerts its action by binding with benzodiazepine which causes enhancing effect of the binding effect of the neurons that results to inhibition of synaptic transmission across the CNS. This drug does not affect the GABA levels.

There are some precautions to be followed while taking this drug. It has been emphasized that caution should be given on elderly patients because they are prone to falls, impairments and drug accumulation. This drug is also given to user who are under 18 years old below because it could be very hazardous for patients at the very young age. This drug is not also recommended to patients who are taking other drugs like carbamazepine and phenytoin. This drug could also impair one’s ability to drive and operate heavy machinery. Alcohol consumption makes the central nervous system depress its effects. Patients who are physically dependent on this drug should be slowly titrated off under the supervision of a doctor to reduce the intensity of withdrawal symptoms. This drug is not also for pregnant women and lactating mothers because there have been medical evidence that the effect of this drug causes various malformations like cardiac or facial deformations and and also decreases IQ level when used in early pregnancy.